Define escort protein
Molloy CM, van de Pol TJ, Brohet RM, Ropers HH, Cremers FP (May 1992).
RAB geranylgeranyl transferase holoenzyme.
Rab proteins are a large family of monomeric GTPases with 60 members identified in the human genome.Cremers FP, Armstrong SA, Seabra MC, Brown MS, Goldstein JL (1994)."Crystallization and preliminary X-ray diffraction analysis of the Rab escort protein-1 in complex with Rab geranylgeranyltransferase".7 10, clinical significance edit, mutations in this gene are a cause of choroideremia ; also known as tapetochoroidal dystrophy (TCD).Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their, c-terminus to localize to the correct intracellular membrane.Seabra MC, Brown MS, Goldstein JL (1993).
"Missense mutation in the choroideremia gene".
Rab GTPases require an isoprenyl modification to their C-terminus for membrane association and function in the regulation of vesicular trafficking pathways.
"Cytosolic RAB3D is associated with RAB escort protein (REP not RAB-GDP dissociation inhibitor (GDI in dispersed chief cells from guinea pig stomach".
Alexandrov K, Simon I, Iakovenko A, Holz B, Goody RS, Scheidig AJ (Apr 1998).
6 See also edit References edit a b c GRCh38: Ensembl release 89: ensg Ensembl, May 2017 a b c GRCm38: Ensembl release 89: ensmusg Ensembl, May 2017 "Human PubMed Reference."Allosteric regulation of substrate binding and product release in geranylgeranyltransferase type II"."Structural determinants of Rab and Rab Escort Protein interaction: Rab family motifs define a conserved binding surface"."REP-2, a Rab escort protein encoded by the choroideremia-like gene".In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them escort 1999 tabela fipe to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction.Alexandrov K, Simon I, Iakovenko A, Holz B, Goody RS, Scheidig AJ (1998).
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